A Single Dose of Kudzu Extract Reduces Alcohol Consumption in a Binge Drinking Paradigm PMC

Animal studies suggest that kudzu root could have heart-protective benefits. It may help regulate blood pressure in patients diagnosed with primary hypertension, a risk factor for heart disease. Along with easing uncomfortable symptoms, estrogen can help prevent bone loss after menopause. In Traditional Chinese Medicine, kudzu root can be used for lots of health purposes. Some common applications include treating fevers and easing symptoms of diabetes.

What does kuzu mean in Japanese?

kuzu (definite accusative kuzuyu, plural kuzular) lamb. sweetheart, sweetie.

Almost 3 in 4 participants had less intense headaches, more than half had fewer headaches, and 1 in 3 had shorter headaches when taking kudzu root. Kudzu root is an edible part of a climbing vine that’s native to many Asian countries. It’s been used for health purposes in Traditional Chinese Medicine for a really long time. Anecdotal sources also note that kudzu root may lower blood sugar too much or slow down blood clotting.

Does Kudzu Root Really Work? Here’s What We Know

At the time of writing, there were no well-known side effects caused by this supplement. David Cozzo, a specialist with the Cooperative Extension Service for the Eastern Band of Cherokee Indians, has given a talk on the benefits on invasive plants, including kudzu. But she also suspected she was underplaying this incredible but destructive plant, so she referred me to an excellent article on the history and impact of kudzu published by the Alabama Cooperative Extension System in 2014. Many people have reported success soaking infected nails in 1 part vinegar to 2 parts water. Such remedies won’t work for everyone and take several months to produce results. A. Policosanol is a natural compound derived from sugar-cane wax, beeswax or yams. While it might not lower cholesterol as well as statin-type medicines, data suggest it can lower bad LDL cholesterol and even raise good HDL cholesterol. It’s important to seek AUD treatment only from a qualified healthcare professional or facility.

  • Kudzu root is linked to a wide range of potential health benefits from easing menopausal symptoms to treating alcohol dependence.
  • An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting.
  • For targeting alcohol dependence, studies have used dosages of 1.2 grams of kudzu root extract per day over 1 week, or a single dose of 2 grams before drinking alcohol, without noted side effects .
  • Anthraquinones are a class of naturally occurring compounds prized for their medicinal properties, as well as for other applications, including ecologically friendly dyes.

Findings show that subjects who took kudzu drank an average of 1.8 beers per session, compared with the 3.5 beers consumed by those who took a placebo. Various herbs and combinations of herbs are reported to be effective in reducing cravings, but in general, no studies have proven their effectiveness. Various herbs and combinations of herbs are reported to be effective in reducing cravings, but in general, no studies have been conducted to prove their effectiveness. For a final session, they took whichever pill they didn’t take the first time. They took it for a week, then went to the lab again for a drinking session. However, studies looking at the effects of kudzu extracts have produced mixed findings, Penetar says. Penetar DM, Teter CJ, Ma Z, Tracy M, Lee DY-W, Lukas SE. Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers. Overstreet DH, Kralic JE, Morrow AL, Ma ZZ, Zhang YW, Lee DY. NPI-031G reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists.

Scott E. Lukas

More studies would be needed to see if it works the same way in humans. The alcohol-targeted acupuncture cut down on cravings and withdrawal symptoms better than the sham treatment. A 2012 study on the kudzu species Pueraria mirifica suggests that doses of 50 to 100 milligrams of kudzu root per day have a low risk of negative side effects. There’s some evidence that kudzu root supplements may cause liver injury, but more research needs to be done on this topic. According to a 2019 animal study, kudzu root may also help regulate blood sugar levels by inhibiting PTP1B, a diabetes-related protein.
kudzu root for alcohol cravings
This may have important anti-alcohol relapse benefits based on dopaminergic genetics and its relationship to executive function and good decision making necessary for appropriate relapse prevention . While the literature seems to support an effect of Kudzu and especially isoflavonoid constituents to suppress ethanol intake in animal models, in contrast, Shebek and Rindone were unable to reproduce this effect in humans. Specifically, in a prospective, randomized, double-blind controlled clinical trial they found no difference between Kudzu and placebo after a one month treatment period in either reducing alcohol craving and or promoting sobriety. In one study, people who binge drink took either kudzu extract or a placebo before a 90-minute session of drinking beer. For reducing alcohol intake, a single dose of 2 grams before drinking alcohol has been effective on participants without causing significant side effects. Keung, not directly involved in Lukas’ study, said he has extracted a compound from kudzu root that he hopes to turn into a drug for reducing alcoholics’ cravings. A deficiency of this enzyme reduces the risk of alcohol dependence. Decreased drinking due to ALDH-2 inhibition is attributed to the aversive properties of acetaldehyde accumulated during alcohol consumption. However, daidzin can reduce drinking in some rodents without necessarily increasing acetaldehyde. A pilot study exploring the effect of kudzu root on the drinking habits of patients with chronic alcoholism.

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She also noted that kudzu has some use as forage for animals, and some people produce kudzu jelly from its flowers, which have a pleasant grape aroma. A. Several studies have indicated that even recommended amounts of vitamin A might weaken bones and lead to fractures. But new research suggests that normal doses of beta carotene and vitamin A are not related to fracture risk. “You want to make sure that your medication is not as bad or worse than the drug you’re trying to treat,” Lukas said. The remains of a medieval skeleton has shown the first physical evidence that a fern plant could have been used for medicinal purposes in cases such as alopecia, dandruff and kidney … Anthraquinones are a class of naturally occurring compounds prized for their medicinal properties, as well as for other applications, including ecologically friendly dyes.

For the researchers, the next step is to determine if kudzu alters regional brain blood flow using an fMRI. The researchers observed 12 men and women in a double-blind placebo-controlled study. The participants were either treated with kudzu or a placebo for nine days, and then received a medium or high alcohol challenge to determine how prominently they presented alcohol-related symptoms. One of the herbals in Declincol, Gentian, is considered the king of the bitter herbs. In tests, it was found that the bitter taste from Gentian can still be perceived even when diluted down to 1 part in 12,000 . Tangerine Peel has some bitter qualities as well, and is an excellent complement to the actions of Gentian. Tangerine Peel delivers several novel flavonoids that all offer numerous health advantages including enhancing metabolism, promoting detoxification, and protecting cells from free radical damage. Most importantly extracts of Tangerine Peel have been shown to enhance learning and memory. Kawahata et al. recently reported on the enhancement properties of Tangerine Peel extracts to facilitate potently- mediated transcription linked to the upstream cAMP/PKA/ERK/CREB pathway in hippocampal neurons.

Arno Kroner, DAOM, LAc, is a board-certified acupuncturist, herbalist, and integrative medicine doctor practicing in Santa Monica, California. Verywell Health’s content is for informational and educational purposes only. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Eucalyptus oil is known to have herbicidal, antifungal, and antimicrobial properties. Red root has been touted as a treatment for things from respiratory issues to UTIs. We’re separating fact from fiction on this homeopathic remedy. Kudzu root is the edible root of a vine plant that’s native to several Asian countries. Other research suggests that kudzu supplements may also play a role in preventing migraine attacks. These are exciting findings, but much more research is needed before we can be sure. One study on 82 postmenopausal women notes that using a Pueraria mirifica gel may improve symptoms of vaginal dryness.
Eco Sober House
The current evidence favors the safety of Kudzu root although some have questioned the potential build- up of acetaldehyde following its administration to humans . On the other side of the safety issue, Singh et al. evaluated the protective effects of puerarin from kudzu root against alcohol-induced toxicities. Alcohol withdrawal after 70 days of drinking generated severe withdrawal symptoms including seizure-type EEG activity. Puerarin suppressed the addictionmediated abnormalities but did not affect the inflammation-related abnormalities. A standardized kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers. Another study found that kudzu may really “affect alcohol consumption patterns.” In this same study, people who took an isoflavone extract from the kudzu plant before drinking took longer to reach for the liquor cabinet.

Data suggest that the administration of kudzu root extract does not disturb sleep/wake cycles of moderate drinkers, and as such its utility as an adjunct treatment for alcohol dependence remains free of any potential side-effects on sleep. The herb called the kudzu is a high climbing, coarse textured twining and trailing type of perennial vine found in parts of Asia and naturalized elsewhere . Chinese traditional medicine makes use of the huge root that grows to the size of an adult human body-the kudzu called gégen in China, is a major source for many modern herbal products as well as traditional Chinese medications. In China, the kudzu or gégen is found growing in shaded areas along mountains, in the fields and along roadsides, in thickets and thin forests all over the country. Herbal products are also made from the root of another related Asian species of kudzu, called Pueraria thomsonii. The main compounds found in the root of the kudzu are the isoflavones, like the compound daidzein, also included are the isoflavone glycosides, like daidzin and the compound called puerarin. In any batch of kudzu roots, the total content of isoflavone often varies widely from 1.77%-12.0% depending on the growing conditions of the herb. The compound puerarin is always found in the highest concentration among all the isoflavones, second is daidzin, followed by daidzein.

What problems does kudzu cause?

Furthermore, the researchers found that kudzu caused a doubling of emissions of nitrogen oxide from soils–along with volatile organic compounds, the key precursor to ozone pollution in the lower atmosphere, and the main component of urban smog.

“Without a doubt, kudzu is here to stay. Although landowners can get effective kudzu control, eradication from the United States is not currently feasible.” They are also interested in the possibility of developing a dosage of kudzu that individuals could take once, before a night of drinking, rather than a set of pills which must be taken regularly. “All addicting drugs activate that part of the brain,” he says. “And a key player in the response Sober House to alcohol and addicting drugs is an increase in dopamine in that brain region.” And those cravings are rooted in a specific part of the brain that’s activated whenever we feel pleasure. The mental health of children and young people with some long term physical conditions could benefit from cognitive behavioral therapy , according to a recent study. More than half of young adults at risk for alcohol-related harm report symptoms of insomnia.

Cytisine is a plant-based alkaloid found in the seeds of the golden rain tree . It works similar to the drug varenicline and has been available in Eastern Europe since the 1960s. The leaves of this plant were smoked by Russian soldiers during World War II when there was a shortage of tobacco. Is considered safe, with few side effects other than the potential for an allergic reaction to the plant. Is one of the earliest medicinal plants used in traditional kudzu root for alcohol cravings Chinese medicine. It has many profound pharmacological actions, including antidipsotropic activity. The first session was to make the participants familiar with the surroundings. Bouchery EE, Harwood HJ, Sacks JJ, Simon CJ, Brewer RD. Economic costs of excessive alcohol consumption in the U.S., 2006. Reducing effect of the Chinese medicinal herb, Salvia miltiorrhiza, on alcohol self-administration in Sardinian alcohol-preferring rats.
kudzu root for alcohol cravings
Some species of kudzu root may be more efficient to treat certain issues. Pueraria lobate, for example, is the species normally used to reduce alcohol cravings. While kudzu root has a long history in traditional Chinese medicine, people most often use it to help treat alcohol dependence. It may also have other benefits, such as for menopausal symptoms. There is some evidence that kudzu root dietary supplements may cause liver injury. One study in mice found that taking 10 mg per day of kudzu root extract for 4 weeks caused liver toxicity . During the baseline session, the placebo-randomized group consumed 2.7 ± 0.78 beers before treatment and increased consumption to 3.4 ± 1.1 beers after treatment. The kudzu group significantly reduced consumption from 3.0 ± 1.7 at baseline to 1.9 ± 1.3 beers after treatment. The placebo-treated group opened 33 beers during baseline conditions and 38 following treatment whereas the kudzu-treated group opened 32 beers during baseline conditions and only 21 following treatment.

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